Putting a water-based bottom paint (WBP) over a solvent based primer can be done with some modified application procedures. You do NOT want to make the window, or hot coat the water based paint over the solvent based primer such as Tuff Stuff high build marine epoxy primer. If you do, it will mud crack. So instead of putting on the WBP over the Solvent Primer in the same day, you need to wait for the primer to totally cure. Then you have to sand it with 80 grit sandpaper before apply WBP. This is a lot of extra work and very difficult to sand = extremely hard surface. So the best thing to do when using a high build solvent based epoxy is to coat it with a solvent based paint. That way you skip the extra time and labor with sanding.